Shared genetic factors in migraine and depression: evidence from a genetic isolate.

ABSTRACT:

Objective

To investigate the co-occurrence of migraine and depression and assess whether shared genetic factors may underlie both diseases.

Methods

Subjects were 2,652 participants of the Erasmus Rucphen Family genetic isolate study. Migraine was diagnosed using a validated 3-stage screening method that included a telephone interview. Symptoms of depression were assessed using the Center for Epidemiologic Studies Depression scale and the depression subscale of the Hospital Anxiety and Depression Scale (HADS-D). The contribution of shared genetic factors in migraine and depression was investigated by comparing heritability estimates for migraine with and without adjustment for symptoms of depression, and by comparing the heritability scores of depression between migraineurs a

SUBMITTER: Stam AH 

PROVIDER: S-EPMC3122301 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature