The Hog1 mitogen-activated protein kinase mediates a hypoxic response in Saccharomyces cerevisiae.

ABSTRACT: We have studied hypoxic induction of transcription by studying the seripauperin (PAU) genes of Saccharomyces cerevisiae. Previous studies showed that PAU induction requires the depletion of heme and is dependent upon the transcription factor Upc2. We have now identified additional factors required for PAU induction during hypoxia, including Hog1, a mitogen-activated protein kinase (MAPK) whose signaling pathway originates at the membrane. Our results have led to a model in which heme and ergosterol depletion alters membrane fluidity, thereby activating Hog1 for hypoxic induction. Hypoxic activation of Hog1 is distinct from its previously characterized response to osmotic stress, as the two conditions cause different transcriptional consequences. Furthermore, Hog1-dependent hypoxic activati

SUBMITTER: Hickman MJ 

PROVIDER: S-EPMC3122313 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature