Increased mitochondrial content in remyelinated axons: implications for multiple sclerosis.

ABSTRACT: Mitochondrial content within axons increases following demyelination in the central nervous system, presumably as a response to the changes in energy needs of axons imposed by redistribution of sodium channels. Myelin sheaths can be restored in demyelinated axons and remyelination in some multiple sclerosis lesions is extensive, while in others it is incomplete or absent. The effects of remyelination on axonal mitochondrial content in multiple sclerosis, particularly whether remyelination completely reverses the mitochondrial changes that follow demyelination, are currently unknown. In this study, we analysed axonal mitochondria within demyelinated, remyelinated and myelinated axons in post-mortem tissue from patients with multiple sclerosis and controls, as well as in experimental models

SUBMITTER: Zambonin JL 

PROVIDER: S-EPMC3122369 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature