Development, evaluation, and application of an in silico model for antimalarial drug treatment and failure.

ABSTRACT: Pharmacological mechanism-based modeling was refined and used to develop an in silico model of antimalarial drug treatment validated against clinical and field data. We used this approach to investigate key features of antimalarial drug action and effectiveness, with emphasis on the current generation of artemisinin combination therapies. We made the following conclusions. (i) The development of artemisinin tolerance and resistance will, unless checked, have an immediate, large impact on the protection afforded to its partner drug and on the likely clinical efficacy of artemisinin combination therapies. (ii) Long follow-up periods are required in clinical trials to detect all drug failures; the follow-up periods of 28 days recommended by the World Health Organization are likely to miss at

SUBMITTER: Winter K 

PROVIDER: S-EPMC3122393 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature