Inhibition of herpes simplex virus type 1 and type 2 infections by peptide-derivatized dendrimers.

ABSTRACT: In response to the need for new antiviral agents, dendrimer-based molecules have been recognized as having a large number of potential therapeutic applications. They include peptide-derivatized dendrimers, which are hyperbranched synthetic well-defined molecules which consist of a peptidyl branching core and covalently attached surface functional peptides. However, few studies have addressed their applications as direct-acting antiviral agents. Here, we report on the ability of the peptide dendrimer SB105 and its derivative, SB105_A10, to directly inhibit herpes simplex virus 1 (HSV-1) and HSV-2 in vitro replication, with favorable selective indexes discerned for both compounds. An analysis of their mode of action revealed that SB105 and SB105_A10 prevent HSV-1 and HSV-2 attachment to targ

SUBMITTER: Luganini A 

PROVIDER: S-EPMC3122415 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature