Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression.

ABSTRACT: Development and homeostasis of multicellular organisms relies on an intricate balance between cell proliferation and differentiation. Geminin regulates the cell cycle by directly binding and inhibiting the DNA replication licensing factor Cdt1. Geminin also interacts with transcriptional regulators of differentiation and chromatin remodelling factors, and its balanced interactions are implicated in proliferation-differentiation decisions during development. Here, we describe Idas (Idas being a cousin of the Gemini in Ancient Greek Mythology), a previously uncharacterised coiled-coil protein related to Geminin. We show that human Idas localizes to the nucleus, forms a complex with Geminin both in cells and in vitro through coiled-coil mediated interactions, and can change Geminin subcellula

SUBMITTER: Pefani DE 

PROVIDER: S-EPMC3123090 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature