Ontology highlight
ABSTRACT:
SUBMITTER: Bruno IG
PROVIDER: S-EPMC3123134 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Molecular cell 20110501 4
Nonsense-mediated decay (NMD) degrades both normal and aberrant transcripts harboring stop codons in particular contexts. Mutations that perturb NMD cause neurological disorders in humans, suggesting that NMD has roles in the brain. Here, we identify a brain-specific microRNA-miR-128-that represses NMD and thereby controls batteries of transcripts in neural cells. miR-128 represses NMD by targeting the RNA helicase UPF1 and the exon-junction complex core component MLN51. The ability of miR-128 t ...[more]