Large-scale analysis of expression signatures reveals hidden links among diverse cellular processes.

ABSTRACT:

Background

Cells must respond to various perturbations using their limited available gene repertoires. In order to study how cells coordinate various responses, we conducted a comprehensive comparison of 1,186 gene expression signatures (gene lists) associated with various genetic and chemical perturbations.

Results

We identified 7,419 statistically significant overlaps between various published gene lists. Most (80%) of the overlaps can be represented by a highly connected network, a "molecular signature map," that highlights the correlation of various expression signatures. By dissecting this network, we identified sub-networks that define clusters of gene sets related to common biological processes (cell cycle, immune response, etc). Examination of these sub-networks has

SUBMITTER: Ge SX 

PROVIDER: S-EPMC3123203 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature