Genome-wide dynamics of a bacterial response to antibiotics that target the cell envelope.

ABSTRACT:

Background

A decline in the discovery of new antibacterial drugs, coupled with a persistent rise in the occurrence of drug-resistant bacteria, has highlighted antibiotics as a diminishing resource. The future development of new drugs with novel antibacterial activities requires a detailed understanding of adaptive responses to existing compounds. This study uses Streptomyces coelicolor A3(2) as a model system to determine the genome-wide transcriptional response following exposure to three antibiotics (vancomycin, moenomycin A and bacitracin) that target distinct stages of cell wall biosynthesis.

Results

A generalised response to all three antibiotics was identified which involves activation of transcription of the cell envelope stress sigma factor σ(E), together with elemen

SUBMITTER: Hesketh A 

PROVIDER: S-EPMC3123327 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature