Cardiac resynchronization by cardiosphere-derived stem cell transplantation in an experimental model of myocardial infarction.

ABSTRACT:

Background

Cardiosphere-derived stem cell (CDC) transplantation can improve global left ventricular ejection fraction (LVEF) after myocardial infarction (MI). The aim of this study was to examine the effects of CDC transplantation on regional function and dyssynchrony after MI.

Methods

Two million rat CDCs (n = 7) or phosphate-buffered saline (n = 7) was injected into the infarct regions of Wistar Kyoto rats. Infarct size and CDC localization were evaluated by positron emission tomography (n = 7). Two-dimensional and strain echocardiography were performed at 1 and 4 weeks after MI. LVEF, circumferential strain, and time to peak circumferential strain were measured in the basal and apical short-axis views. Dyssynchrony was defined as the maximal difference of time to peak cir

SUBMITTER: Bonios M 

PROVIDER: S-EPMC3123416 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature