Modeling microRNA-mRNA interactions using PLS regression in human colon cancer.

ABSTRACT:

Background

Changes in microRNA (miRNA) expression patterns have been extensively characterized in several cancers, including human colon cancer. However, how these miRNAs and their putative mRNA targets contribute to the etiology of cancer is poorly understood. In this work, a bioinformatics computational approach with miRNA and mRNA expression data was used to identify the putative targets of miRNAs and to construct association networks between miRNAs and mRNAs to gain some insights into the underlined molecular mechanisms of human colon cancer.

Method

The miRNA and mRNA microarray expression profiles from the same tissues including 7 human colon tumor tissues and 4 normal tissues, collected by the Broad Institute, were used to identify significant associations between miRN

SUBMITTER: Li X 

PROVIDER: S-EPMC3123543 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature