NCACO-score: an effective main-chain dependent scoring function for structure modeling.

ABSTRACT:

Background

Development of effective scoring functions is a critical component to the success of protein structure modeling. Previously, many efforts have been dedicated to the development of scoring functions. Despite these efforts, development of an effective scoring function that can achieve both good accuracy and fast speed still presents a grand challenge.

Results

Based on a coarse-grained representation of a protein structure by using only four main-chain atoms: N, Cα, C and O, we develop a knowledge-based scoring function, called NCACO-score, that integrates different structural information to rapidly model protein structure from sequence. In testing on the Decoys'R'Us sets, we found that NCACO-score can effectively recognize native conformers from their decoys. Furthe

SUBMITTER: Tian L 

PROVIDER: S-EPMC3123610 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature