A miRNA expression signature that separates between normal and malignant prostate tissues.

ABSTRACT:

Background

MicroRNAs (miRNAs) constitute a class of small non-coding RNAs that post-transcriptionally regulate genes involved in several key biological processes and thus are involved in various diseases, including cancer. In this study we aimed to identify a miRNA expression signature that could be used to separate between normal and malignant prostate tissues.

Results

Nine miRNAs were found to be differentially expressed (p <0.00001). With the exception of two samples, this expression signature could be used to separate between the normal and malignant tissues. A cross-validation procedure confirmed the generality of this expression signature. We also identified 16 miRNAs that possibly could be used as a complement to current methods for grading of prostate tumor tissues.<

SUBMITTER: Carlsson J 

PROVIDER: S-EPMC3123620 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature