Medical radiation exposure and risk of retinoblastoma resulting from new germline RB1 mutation.

ABSTRACT: Although ionizing radiation induces germline mutations in animals, human studies of radiation-exposed populations have not detected an effect. We conducted a case-control study of sporadic bilateral retinoblastoma, which results from a new germline RB1 mutation, to investigate gonadal radiation exposure of parents from medical sources before their child's conception. Parents of 206 cases from nine North American institutions and 269 controls participated; fathers of 184 cases and 223 friend and relative controls and mothers of 204 cases and 260 controls provided information in telephone interviews on their medical radiation exposure. Cases provided DNA for RB1 mutation testing. Of common procedures, lower gastrointestinal (GI) series conferred the highest estimated dose to testes and ovari

SUBMITTER: Bunin GR 

PROVIDER: S-EPMC3124307 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature