Tissue and serum microRNAs in the Kras(G12D) transgenic animal model and in patients with pancreatic cancer.

ABSTRACT: microRNAs (miRs) modulate the expression levels of mRNAs and proteins and can thus contribute to cancer initiation and progression. In addition to their intracelluar function, miRs are released from cells and shed into the circulation. We postulated that circulating miRs could provide insight into pathways altered during cancer progression and may indicate responses to treatment. Here we focus on pancreatic cancer malignant progression. We report that changes in miR expression patterns during progression of normal tissues to invasive pancreatic adenocarcinoma in the p48-Cre/LSL-Kras(G12D) mouse model mirrors the miR changes observed in human pancreatic cancer tissues. miR-148a/b and miR-375 expression were found decreased whereas miR-10, miR-21, miR-100 and miR-155 were increased when comp

SUBMITTER: LaConti JJ 

PROVIDER: S-EPMC3124473 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature