Characterization of protein-protein interaction interfaces from a single species.

ABSTRACT: Most proteins attain their biological functions through specific interactions with other proteins. Thus, the study of protein-protein interactions and the interfaces that mediate these interactions is of prime importance for the understanding of biological function. In particular the precise determinants of binding specificity and their contributions to binding energy within protein interfaces are not well understood. In order to better understand these determinants an appropriate description of the interaction surface is needed. Available data from the yeast Saccharomyces cerevisiae allow us to focus on a single species and to use all the available structures, correcting for redundancy, instead of using structural representatives. This allows us to control for potentially confounding fact

SUBMITTER: Talavera D 

PROVIDER: S-EPMC3124478 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature