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Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome.

ABSTRACT: Two cohorts of women with polycystic ovary syndrome (PCOS), comprising 400 probands and affected sisters in 365 families and a case-control group including 395 women with PCOS and 171 healthy women with regular menstrual cycles, were studied to determine whether single-nucleotide polymorphisms (SNPs) identified as susceptibility loci in genomewide association studies of type 2 diabetes are also associated with PCOS. None of the 18 allelic variants in 10 genes previously shown to be associated with type 2 diabetes were found to be associated with PCOS, but some were associated with indices of beta cell function.

SUBMITTER: Ewens KG 

PROVIDER: S-EPMC3124609 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature

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Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome.

Ewens Kathryn G KG   Jones Michelle R MR   Ankener Wendy W   Stewart Douglas R DR   Urbanek Margrit M   Dunaif Andrea A   Legro Richard S RS   Chua Angela A   Azziz Ricardo R   Spielman Richard S RS   Goodarzi Mark O MO   Strauss Jerome F JF  

Fertility and sterility 20110327 8

Two cohorts of women with polycystic ovary syndrome (PCOS), comprising 400 probands and affected sisters in 365 families and a case-control group including 395 women with PCOS and 171 healthy women with regular menstrual cycles, were studied to determine whether single-nucleotide polymorphisms (SNPs) identified as susceptibility loci in genomewide association studies of type 2 diabetes are also associated with PCOS. None of the 18 allelic variants in 10 genes previously shown to be associated wi  ...[more]

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