Characterization of Lovastatin biosynthetic cluster proteins in Aspergillus terreus strain ATCC 20542.

ABSTRACT: Aspergillus terreus is a filamentous ascomycota, which is prominent for its production of lovastatin, an antihypercholesterolemic drug. The commercial importance of lovastatin with annual sales of billions of dollars made us to focus on lovastatin biosynthetic cluster proteins. The analysis of these lovastatin biosynthetic cluster proteins with different perspectives such as physicochemical property, structure based analysis and functional studies were done to find out the role and function of every protein involved in the lovastatin biosynthesis pathway. Several computational tools are used to predict the physicochemical properties, secondary structural features, topology, patterns, domains and cellular location. There are 8 unidentified proteins in lovastatin biosynthetic cluster, in whi

SUBMITTER: Subazini TK 

PROVIDER: S-EPMC3124688 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature