Physicochemical characterization and functional site analysis of lactoferrin gene of Vechur cow.

ABSTRACT: The Bos indicus Vechur breed cow milk is known for its medicinal value and the breed is listed under the category of critically maintained breeds by the Food and Agriculture Organization. The lactoferrin protein in milk is known for its nutritional value. Gene polymorphisms have been reported for Bovine lactoferrin. Mutations in the evolutionarily conserved sites tend to impair protein function and are related with the physicochemical difference between the known variants with 11 SNPs within the wild type. Structural differences are located due to these SNPs that may lead to functional variations. The structural variation is seen primarily in the first 48 residues at 5' end in all the samples modelled. Out of 11 SNPs 5 amino acid variations fall under alpha helix and beta sheet region, thi

SUBMITTER: Shashidharan A 

PROVIDER: S-EPMC3124693 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature