Molecular profiles of mitogen activated protein kinase signaling pathways in orofacial development.

ABSTRACT:

Background

Formation of the mammalian orofacial region involves multiple signaling pathways regulating sequential expression of and interaction between molecular signals during embryogenesis. The present study examined the expression patterns of members of the MAPK family in developing murine orofacial tissue.

Methods

Total RNA was extracted from developing embryonic orofacial tissue during gestational days (GDs) 12-14 and used to prepare biotinylated cDNA probes, which were then denatured and hybridized to murine MAPK signaling pathways gene arrays.

Results

Expression of a number of genes involved in the (ERK1/2) cascade transiently increased in the embryonic orofacial tissue over the developmental period examined. Numerous members of the SAPK/JNK cascade were consti

SUBMITTER: Singh S 

PROVIDER: S-EPMC3124958 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature