Developmental transcriptomic features of the carcinogenic liver fluke, Clonorchis sinensis.

ABSTRACT: Clonorchis sinensis is the causative agent of the life-threatening disease endemic to China, Korea, and Vietnam. It is estimated that about 15 million people are infected with this fluke. C. sinensis provokes inflammation, epithelial hyperplasia, and periductal fibrosis in bile ducts, and may cause cholangiocarcinoma in chronically infected individuals. Accumulation of a large amount of biological information about the adult stage of this liver fluke in recent years has advanced our understanding of the pathological interplay between this parasite and its hosts. However, no developmental gene expression profiles of C. sinensis have been published. In this study, we generated gene expression profiles of three developmental stages of C. sinensis by analyzing expressed sequence tags (ESTs). C

SUBMITTER: Yoo WG 

PROVIDER: S-EPMC3125140 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature