A tissue-specific landscape of sense/antisense transcription in the mouse intestine.

ABSTRACT:

Background

The intestinal mucosa is characterized by complex metabolic and immunological processes driven highly dynamic gene expression programs. With the advent of next generation sequencing and its utilization for the analysis of the RNA sequence space, the level of detail on the global architecture of the transcriptome reached a new order of magnitude compared to microarrays.

Results

We report the ultra-deep characterization of the polyadenylated transcriptome in two closely related, yet distinct regions of the mouse intestinal tract (small intestine and colon). We assessed tissue-specific transcriptomal architecture and the presence of novel transcriptionally active regions (nTARs). In the first step, signatures of 20,541 NCBI RefSeq transcripts could be identified in t

SUBMITTER: Klostermeier UC 

PROVIDER: S-EPMC3125268 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature