Characterization the regulation of herpesvirus miRNAs from the view of human protein interaction network.

ABSTRACT:

Background

miRNAs are a class of non-coding RNA molecules that play crucial roles in the regulation of virus-host interactions. The ever-increasing data of known viral miRNAs and human protein interaction network (PIN) has made it possible to study the targeting characteristics of viral miRNAs in the context of these networks.

Results

We performed topological analysis to explore the targeting propensities of herpesvirus miRNAs from the view of human PIN and found that (1) herpesvirus miRNAs significantly target more hubs, moreover, compared with non-hubs (non-bottlenecks), hubs (bottlenecks) are targeted by much more virus miRNAs and virus types. (2) There are significant differences in the degree and betweenness centrality between common and specific targets, specifically w

SUBMITTER: Li Z 

PROVIDER: S-EPMC3125315 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature