Genome-wide association study of personality traits in bipolar patients.

ABSTRACT:

Objective

Genome-wide association study was carried out on personality traits among bipolar patients as possible endophenotypes for gene discovery in bipolar disorder.

Methods

The subscales of Cloninger's Temperament and Character Inventory (TCI) and the Zuckerman-Kuhlman Personality Questionnaire (ZKPQ) were used as quantitative phenotypes. The genotyping platform was the Affymetrix 6.0 SNP array. The sample consisted of 944 individuals for TCI and 1007 for ZKPQ, all of European ancestry, diagnosed with bipolar disorder by Diagnostic and Statistical Manual of Mental Disorders-IV criteria.

Results

Genome-wide significant association was found for two subscales of the TCI, rs10479334 with the 'Social Acceptance versus Social Intolerance' subscale (Bonferroni P = 0.014)

SUBMITTER: Alliey-Rodriguez N 

PROVIDER: S-EPMC3125400 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature