An examination of single nucleotide polymorphism selection prioritization strategies for tests of gene-gene interaction.

ABSTRACT:

Background

Given that genome-wide association studies (GWAS) of psychiatric disorders have identified only a small number of convincingly associated variants (single nucleotide polymorphism [SNP]), there is interest in seeking additional evidence for associated variants with tests of gene-gene interaction. Comprehensive pair-wise single SNP-SNP interaction analysis is computationally intensive, and the penalty for multiple testing is severe, given the number of interactions possible. Aiming to minimize these statistical and computational burdens, we have explored approaches to prioritize SNPs for interaction analyses.

Methods

Primary interaction analyses were performed with the Wellcome Trust Case-Control Consortium bipolar disorder GWAS (1868 cases, 2938 control subjects).

SUBMITTER: Moskvina V 

PROVIDER: S-EPMC3125485 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature