High-density fine-mapping of a chromosome 10q26 linkage peak suggests association between endometriosis and variants close to CYP2C19.

ABSTRACT:

Objective

To refine a previously reported linkage peak for endometriosis on chromosome 10q26, and conduct follow-up analyses and a fine-mapping association study across the region to identify new candidate genes for endometriosis.

Design

Case-control study.

Setting

Academic research.

Patient(s)

Cases=3,223 women with surgically confirmed endometriosis; controls=1,190 women without endometriosis and 7,060 population samples.

Intervention(s)

Analysis of 11,984 single nucleotide polymorphisms on chromosome 10.

Main outcome measure(s)

Allele frequency differences between cases and controls.

Result(s)

Linkage analyses on families grouped by endometriosis symptoms (primarily subfertility) provided increased evidence for linkage (logarithm of odds

SUBMITTER: Painter JN 

PROVIDER: S-EPMC3125525 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature