Ontology highlight
ABSTRACT:
SUBMITTER: Williamson A
PROVIDER: S-EPMC3125540 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Molecular cell 20110601 6
Processive reactions, such as transcription or translation, often proceed through distinct initiation and elongation phases. The processive formation of polymeric ubiquitin chains can accordingly be catalyzed by specialized initiating and elongating E2 enzymes, but the functional significance for this division of labor has remained unclear. Here, we have identified sequence motifs in several substrates of the anaphase-promoting complex (APC/C) that are required for efficient chain initiation by ...[more]