Polygenic modeling of genome-wide association studies: an application to prostate and breast cancer.

ABSTRACT: Genome-wide association studies (GWAS) have successfully detected and replicated associations with numerous diseases, including cancers of the prostate and breast. These findings are helping clarify the genomic basis of such diseases, but appear to explain little of disease heritability. This limitation might reflect the focus of conventional GWAS on a small set of the most statistically significant associations with disease. More information might be obtained by analyzing GWAS using a polygenic model, which allows for the possibility that thousands of genetic variants could impact disease. Furthermore, there may exist common polygenic effects between potentially related phenotypes (e.g., prostate and breast cancer). Here we present and apply a polygenic model to GWAS of prostate and breas

SUBMITTER: Witte JS 

PROVIDER: S-EPMC3125548 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature