A phase II randomized placebo-controlled trial of omega-3 fatty acids for the treatment of acute lung injury.

ABSTRACT:

Objectives

Administration of eicosapentaenoic acid and docosahexanoic acid, omega-3 fatty acids in fish oil, has been associated with improved patient outcomes in acute lung injury when studied in a commercial enteral formula. However, fish oil has not been tested independently in acute lung injury. We therefore sought to determine whether enteral fish oil alone would reduce pulmonary and systemic inflammation in patients with acute lung injury.

Design

Phase II randomized controlled trial.

Setting

Five North American medical centers.

Patients

Mechanically ventilated patients with acute lung injury ≥18 yrs of age.

Interventions

Subjects were randomized to receive enteral fish oil (9.75 g eicosapentaenoic acid and 6.75 g docosahexanoic acid daily) or salin

SUBMITTER: Stapleton RD 

PROVIDER: S-EPMC3125670 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature