Preexisting statin use is associated with greater reperfusion in hyperacute ischemic stroke.

ABSTRACT:

Background and purpose

Statin pretreatment has been associated with improved outcomes in patients with ischemic stroke. Although several mechanisms have been examined in animal models, few have been examined in patients. We hypothesized that patients using statins before stroke onset may have greater reperfusion than patients not using statins.

Methods

Acute ischemic stroke patients underwent 2 MR scans: within 4.5 (tp1) and at 6 hours (tp2) after stroke onset. Regions of reperfusion were defined by prolonged mean transit time (MTT) at tp1, which normalized at tp2. Four MTT thresholds were assessed to ensure that results were not spuriously based on an arbitrary threshold. Baseline characteristics, relative reperfusion, and change in NIHSS between tp1 and 1-month follow-up (

SUBMITTER: Ford AL 

PROVIDER: S-EPMC3125694 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature