Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes.

ABSTRACT: The mechanisms by which the epithelium of the digestive tract and its associated glands are specified are largely unknown. One clue is that several transcription factors are expressed in specific regions of the endoderm prior to and during organogenesis. Pdx-1, for example, is expressed in the duodenum and pancreas and Pdx-1 inactivation results in an arrest of pancreatic development after buds formation. Similarly, ngn3 is transiently expressed in the developing pancreas and a knockout results in the absence of endocrine cells. This paper focuses on the question of whether these and other transcription factors, known to be necessary for pancreatic development, are also sufficient to drive a program of pancreatic organogenesis. Using in ovo electroporation of chick embryos, we show that ec

SUBMITTER: Grapin-Botton A 

PROVIDER: S-EPMC312631 | biostudies-literature | 2001 Feb

REPOSITORIES: biostudies-literature