Species-specific variation in RELA underlies differences in NF-κB activity: a potential role in African swine fever pathogenesis.

ABSTRACT: African swine fever virus (ASFV) is a highly infectious disease of domestic pigs, with virulent isolates causing a rapidly fatal hemorrhagic fever. In contrast, the porcine species endogenous to Africa tolerate infection. The ability of the virus to persist in one host while killing another genetically related host implies that disease severity may be, in part, modulated by host genetic variation. To complement transcription profiling approaches to identify the underlying genetic variation in the host response to ASFV, we have taken a candidate gene approach based on known signaling pathways that interact with the virus-encoded immunomodulatory protein A238L. We report the sequencing of these genes from different pig species and the identification and initial in vitro characterization of p

SUBMITTER: Palgrave CJ 

PROVIDER: S-EPMC3126315 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature