Opposing effects of CD70 costimulation during acute and chronic lymphocytic choriomeningitis virus infection of mice.

ABSTRACT: T cell costimulation is important for T cell activation. The CD27/CD70 pathway contributes to effector and memory T cell development and is involved in T cell and B cell activation. CD27/CD70 is known for having opposing roles during different models of antigenic challenges. During primary T cell responses to influenza virus infection or during tumor challenges, CD27/CD70 costimulation has a positive role on T cell responses. However, during some chronic infections, constitutive triggering of this signaling pathway has a negative role on T cell responses. It is currently unclear what specific characteristic of an antigen determines the outcome of CD27/CD70 costimulation. We investigated the effect of a transient CD70 blockade during an acute or a chronic lymphocytic choriomeningitis virus

SUBMITTER: Penaloza-MacMaster P 

PROVIDER: S-EPMC3126534 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature