Functional macroautophagy induction by influenza A virus without a contribution to major histocompatibility complex class II-restricted presentation.

ABSTRACT: Major histocompatibility complex (MHC) class II-presented peptides can be derived from both exogenous (extracellular) and endogenous (biosynthesized) sources of antigen. Although several endogenous antigen-processing pathways have been reported, little is known about their relative contributions to global CD4(+) T cell responses against complex antigens. Using influenza virus for this purpose, we assessed the role of macroautophagy, a process in which cytosolic proteins are delivered to the lysosome by de novo vesicle formation and membrane fusion. Influenza infection triggered productive macroautophagy, and autophagy-dependent presentation was readily observed with model antigens that naturally traffic to the autophagosome. Furthermore, treatments that enhance or inhibit macroautophagy mo

SUBMITTER: Comber JD 

PROVIDER: S-EPMC3126538 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature