Interplay of recombination and selection in the genomes of Chlamydia trachomatis.

ABSTRACT:

Background

Chlamydia trachomatis is an obligate intracellular bacterial parasite, which causes several severe and debilitating diseases in humans. This study uses comparative genomic analyses of 12 complete published C. trachomatis genomes to assess the contribution of recombination and selection in this pathogen and to understand the major evolutionary forces acting on the genome of this bacterium.

Results

The conserved core genes of C. trachomatis are a large proportion of the pan-genome: we identified 836 core genes in C. trachomatis out of a range of 874-927 total genes in each genome. The ratio of recombination events compared to mutation (ρ/θ) was 0.07 based on ancestral reconstructions using the ClonalFrame tool, but recombination had a significant effect on genetic d

SUBMITTER: Joseph SJ 

PROVIDER: S-EPMC3126793 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature