Diffusion tensor imaging and cognitive function in older adults with no dementia.

ABSTRACT:

Objective

To determine the patterns of diffusivity associated with cognitive domain functions in older adults without dementia.

Methods

We studied older adults without dementia (n = 220) who underwent neuropsychometric testing and a diffusion tensor imaging (DTI) examination at 3 T in a cross-sectional study. Memory, language, attention/executive function, and visual-spatial processing domains were assessed within 4 months of the MRI examination. A fluid-attenuated inversion recovery-based DTI sequence that enabled uncontaminated cortical diffusion measurements was performed. Associations between cortical mean diffusivity (MD) and cognitive function were tested using voxel-based regression analysis. Association between tract diffusivity and cognitive function was tested with

SUBMITTER: Kantarci K 

PROVIDER: S-EPMC3127333 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature