Urinary tract stone occurrence in the Women's Health Initiative (WHI) randomized clinical trial of calcium and vitamin D supplements.

ABSTRACT:

Background

The Women's Health Initiative (WHI) randomized clinical trial (RCT) of calcium plus vitamin D (CaD) supplements found a 17% excess in urinary tract stone incidence in the supplemented group. This study evaluated whether this risk is modified by participant characteristics.

Objective

We examined the correlates of urinary tract stone occurrence in the CaD arm of the WHI trial.

Design

We analyzed an RCT involving 36,282 postmenopausal women aged 50-79 y from 40 WHI centers: 18,176 women received 500 mg calcium carbonate plus 200 IU vitamin D(3) twice daily (1000 mg and 400 IU daily, respectively), and 18,106 women received a matching placebo for an average of 7.0 y. The incidence of urinary tract stones was determined.

Results

The incidence of self-repo

SUBMITTER: Wallace RB 

PROVIDER: S-EPMC3127502 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature