Maternal and offspring adiposity-related genetic variants and gestational weight gain.

ABSTRACT:

Background

Gestational weight gain (GWG) is associated with a range of health outcomes, but little is known about the factors that influence it.

Objective

The objective was to test the hypothesis that maternal and fetal genetic variants that are reliably associated with adiposity are associated with GWG.

Design

We examined the association of a risk allele score by using 4 adiposity-related single nucleotide polymorphisms (SNPs; rs9939609 in FTO, rs17782313 near MC4R, rs6548238 near TMEM18, and rs10938397 near GNPDA2) with GWG in a pregnancy cohort in which women had detailed repeated assessment of GWG (median number of weight measurements: 10; interquartile range: 8, 11). The numbers included in our analyses varied between 2324 and 7563 for different variant-outcome a

SUBMITTER: Lawlor DA 

PROVIDER: S-EPMC3127507 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature