Metabolic responses to prolonged consumption of glucose- and fructose-sweetened beverages are not associated with postprandial or 24-h glucose and insulin excursions.

ABSTRACT:

Background

Consumption of sugar-sweetened beverages has been shown to be associated with dyslipidemia, insulin resistance, fatty liver, diabetes, and cardiovascular disease. It has been proposed that adverse metabolic effects of chronic consumption of sugar-sweetened beverages are a consequence of increased circulating glucose and insulin excursions, ie, dietary glycemic index (GI).

Objective

We determined whether the greater adverse effects of fructose than of glucose consumption were associated with glucose and insulin exposures.

Design

The subjects were studied in a metabolic facility and consumed energy-balanced diets containing 55% of energy as complex carbohydrate for 2 wk (GI = 64). The subjects then consumed 25% of energy requirements as fructose- or glucose-s

SUBMITTER: Stanhope KL 

PROVIDER: S-EPMC3127512 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature