Dietary macronutrient composition affects β cell responsiveness but not insulin sensitivity.

ABSTRACT:

Background

Altering dietary carbohydrate or fat content may have chronic effects on insulin secretion and sensitivity, which may vary with individual metabolic phenotype.

Objective

The objective was to evaluate the contribution of tightly controlled diets differing in carbohydrate and fat content for 8 wk to insulin sensitivity and β cell responsiveness and whether effects of diet would vary with race, free-living diet, or insulin response.

Design

Healthy overweight men and women (36 European Americans, 33 African Americans) were provided with food for 8 wk and received either a eucaloric standard diet (55% carbohydrate, 27% fat) or a eucaloric reduced-carbohydrate (RedCHO)/higher-fat diet (43% carbohydrate, 39% fat). Insulin sensitivity and β cell responsiveness were

SUBMITTER: Goree LL 

PROVIDER: S-EPMC3127518 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature