Effects of a low-fat dietary intervention on glucose, insulin, and insulin resistance in the Women's Health Initiative (WHI) Dietary Modification trial.

ABSTRACT:

Background

Glycemic effects of the Women's Health Initiative (WHI) low-fat dietary intervention are unknown.

Objective

Our objective was to analyze the effects of the WHI low-fat dietary intervention on serum glucose and insulin and insulin resistance up to 6 y after random assignment.

Design

Postmenopausal WHI Dietary Modification trial intervention (DM-I) and comparison (DM-C) participants with blood measures at least at baseline and year 1 (n = 2263) were included. Anthropometric measures, dietary assessments, serum glucose and insulin concentrations, homeostasis model assessment of insulin resistance (HOMA-IR) measures, and quantitative insulin sensitivity check index (QUICKI) values were obtained at baseline, year 1, year 3, and year 6. Changes in measures were c

SUBMITTER: Shikany JM 

PROVIDER: S-EPMC3127523 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature