Functional maturation of drug transporters in the developing, neonatal, and postnatal kidney.

ABSTRACT: Because renal function in newborns is immature, the pharmacokinetics of drugs administered to neonates vary significantly from adult patients. The establishment of drug transport systems is a key process in the functional maturation of the nephron. However, a thorough examination of the expression of the main drug transporters in the kidney throughout all stages of development (embryonic, postnatal, and mature) has yet to be carried out, and the functional (physiological) impact is not well understood. Using time-series microarray data, we analyzed the temporal behavior of mRNA levels for a wide range of SLC and ABC transporters in the rodent kidney throughout a developmental time series. We find dynamic increases between the postnatal and mature stages of development for a number of trans

SUBMITTER: Sweeney DE 

PROVIDER: S-EPMC3127534 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature