Trade-off between responsiveness and noise suppression in biomolecular system responses to environmental cues.

ABSTRACT: When living systems detect changes in their external environment their response must be measured to balance the need to react appropriately with the need to remain stable, ignoring insignificant signals. Because this is a fundamental challenge of all biological systems that execute programs in response to stimuli, we developed a generalized time-frequency analysis (TFA) framework to systematically explore the dynamical properties of biomolecular networks. Using TFA, we focused on two well-characterized yeast gene regulatory networks responsive to carbon-source shifts and a mammalian innate immune regulatory network responsive to lipopolysaccharides (LPS). The networks are comprised of two different basic architectures. Dual positive and negative feedback loops make up the yeast galactose n

SUBMITTER: Ratushny AV 

PROVIDER: S-EPMC3127798 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature