Structural principles within the human-virus protein-protein interaction network.

ABSTRACT: General properties of the antagonistic biomolecular interactions between viruses and their hosts (exogenous interactions) remain poorly understood, and may differ significantly from known principles governing the cooperative interactions within the host (endogenous interactions). Systems biology approaches have been applied to study the combined interaction networks of virus and human proteins, but such efforts have so far revealed only low-resolution patterns of host-virus interaction. Here, we layer curated and predicted 3D structural models of human-virus and human-human protein complexes on top of traditional interaction networks to reconstruct the human-virus structural interaction network. This approach reveals atomic resolution, mechanistic patterns of host-virus interaction, and fa

SUBMITTER: Franzosa EA 

PROVIDER: S-EPMC3127880 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature