PAPC and the Wnt5a/Ror2 pathway control the invagination of the otic placode in Xenopus.

ABSTRACT:

Background

Paraxial protocadherin (PAPC) plays a crucial role in morphogenetic movements during gastrulation and somitogenesis in mouse, zebrafish and Xenopus. PAPC influences cell-cell adhesion mediated by C-Cadherin. A putative direct adhesion activity of PAPC is discussed. PAPC also promotes cell elongation, tissue separation and coordinates cell mass movements. In these processes the signaling function of PAPC in activating RhoA/JNK and supporting Wnt-11/PCP by binding to frizzled 7 (fz7) is important.

Results

Here we demonstrate by loss of function experiments in Xenopus embryos that PAPC regulates another type of morphogenetic movement, the invagination of the ear placode. Knockdown of PAPC by antisense morpholinos results in deformation of the otic vesicle without alt

SUBMITTER: Jung B 

PROVIDER: S-EPMC3127988 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature