NDRG2 inhibits hepatocellular carcinoma adhesion, migration and invasion by regulating CD24 expression.

ABSTRACT:

Background

The prognosis of most hepatocellular carcinoma (HCC) patients is poor due to the high metastatic rate of the disease. Understanding the molecular mechanisms underlying HCC metastasis is extremely urgent. The role of CD24 and NDRG2 (N-myc downstream-regulated gene 2), a candidate tumor suppressor gene, has not yet been explored in HCC.

Methods

The mRNA and protein expression of CD24 and NDRG2 was analyzed in MHCC97H, Huh7 and L-02 cells. Changes in cell adhesion, migration and invasion were detected by up- or down-regulating NDRG2 by adenovirus or siRNA. The expression pattern of NDRG2 and CD24 in HCC tissues and the relationship between NDRG2 and HCC clinical features was analyzed by immunohistochemical and western blotting analysis.

Results

NDRG2 expressio

SUBMITTER: Zheng J 

PROVIDER: S-EPMC3128008 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature