Minimal regulatory spaces in yeast genomes.

ABSTRACT:

Background

The regulatory information encoded in the DNA of promoter regions usually enforces a minimal, non-zero distance between the coding regions of neighboring genes. However, the size of this minimal regulatory space is not generally known. In particular, it is unclear if minimal promoter size differs between species and between uni- and bi-directionally acting regulatory regions.

Results

Analyzing the genomes of 11 yeasts, we show that the lower size limit on promoter-containing regions is species-specific within a relatively narrow range (80-255 bp). This size limit applies equally to regions that initiate transcription on one or both strands, indicating that bi-directional promoters and uni-directional promoters are constrained similarly. We further find that young,

SUBMITTER: Chen WH 

PROVIDER: S-EPMC3128071 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature