Transcription regulation of sex-biased genes during ontogeny in the malaria vector Anopheles gambiae.

ABSTRACT: In Anopheles gambiae, sex-regulated genes are responsible for controlling gender dimorphism and are therefore crucial in determining the ability of female mosquitoes to transmit human malaria. The identification and functional characterization of these genes will shed light on the sexual development and maturation of mosquitoes and provide useful targets for genetic control measures aimed at reducing mosquito fertility and/or distorting the sex ratio.We conducted a genome wide transcriptional analysis of sex-regulated genes from early developmental stages through adulthood combined with functional screening of novel gonadal genes. Our results demonstrate that the male-biased genes undergo a major transcription turnover starting from larval stages to adulthood. The male biased genes at the

SUBMITTER: Magnusson K 

PROVIDER: S-EPMC3128074 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature