Induction of immune mediators in glioma and prostate cancer cells by non-lethal photodynamic therapy.

ABSTRACT:

Background

Photodynamic therapy (PDT) uses the combination of photosensitizing drugs and harmless light to cause selective damage to tumor cells. PDT is therefore an option for focal therapy of localized disease or for otherwise unresectable tumors. In addition, there is increasing evidence that PDT can induce systemic anti-tumor immunity, supporting control of tumor cells, which were not eliminated by the primary treatment. However, the effect of non-lethal PDT on the behavior and malignant potential of tumor cells surviving PDT is molecularly not well defined.

Methodology/principal findings

Here we have evaluated changes in the transcriptome of human glioblastoma (U87, U373) and human (PC-3, DU145) and murine prostate cancer cells (TRAMP-C1, TRAMP-C2) after non-lethal PDT

SUBMITTER: Kammerer R 

PROVIDER: S-EPMC3128096 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature