Association between a serotonin transporter promoter polymorphism (5HTTLPR) and personality disorder traits in a community sample.

ABSTRACT:

Background

The serotonin transporter (SERT) polymorphism (5HTTLPR) has been reported to be associated with several psychiatric conditions. Specific personality disorders could be intermediate factors in the known relationship between 5HTTLPR and psychiatric disorders. This is the first study to test the association between this polymorphism and dimensions of all DSM-IV personality disorders in a community sample.

Methods

374 white participants were assessed by clinical psychologists using the International Personality Disorder Examination (IPDE). Associations between dimensions of each DSM-IV personality disorder and the long (l) and short (s) alleles of the 5HTTLPR were evaluated using non-parametric tests and regression models.

Results

The s allele of the 5HTTLPR po

SUBMITTER: Blom RM 

PROVIDER: S-EPMC3128677 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature